616.234.5000

Publications

Russell Jones Laboratory

Publications

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Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. 2018. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science 361(6400):406–411.

Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. 2018. Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metab.

Guak H, Al Habyan S, Ma EH, Aldossary H, Al-Masri M, Won SY, Ying T, Fixman ED, Jones RG, McCaffrey LM, Krawczyk CM. 2018. Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration. Nat Commun 9(1):2463.

Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. 2018. The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting. EMBO Mol Med 10(7).

Tzelepis F, Blagih J, Khan N, Gillard J, Mendonca L, Roy DG, Ma EH, Joubert P, Jones RG, Divangahi M. 2018. Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis. Sci Immunol 3(23).

Raud B, McGuire PJ, Jones RG, Sparwasser T, Berod L. 2018. Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts. Immunol Rev 283(1):213-231.

Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG, Piccirillo CA, Siegel PM, Sonenberg N. 2018. Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. Proc Natl Acad Sci U S A 115(10):E2202-E2209.

Rabinovitch R, Samborska B, Faubert B, Gravel S-P, Andrzejewski S, Ma EH, Raissi TC, Pause A, St.-Pierre J, Jones RG. 2017. AMPK maintains cellular metabolic homeostasis through regulation of mitochondrial reactive oxygen species. Cell Rep 21(1):1–9.

Jones RG, Pearce EJ. 2017. MenTORing immunity: mTOR signaling in the development and function of tissue resident immune cells. Immunity 46(5):730–742.

Ma EH, Poffenberger MC, Wong AH-T, Jones RG. 2017. The role of AMPK in T cell metabolism and function. Curr Opin Immunol 46:45–52.

Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer M, Verway MJ, Raissi TC, Tsui H, Boukhaled G, da Costa SH, Frezza C, Krawczyk CM, Richer MJ, Hess C, Jones RG. 2017. Serine is an essential metabolite for effector T cell expansion. Cell Metab 25(2):345–357.

Carbonneau MM, Gagné L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot MÉ, Mallette FA. 2016. The oncometabolite 2-hydroxyglutarate activates the mTOR signaling pathway. Nat Commun 7:12700.

Lehuédé C, Dupuy F, Rabinovitch R, Jones RG, Siegel PM. 2016. Metabolic plasticity as a determinant of tumour growth and metastasis. Cancer Res 76(18):5201–5208.

Izreig S, Samborska B, Johnson RM, Sergushichev A, Ma EH, Lussier C, Donayo AO, Sagan SM, Vincent EE, Artyomov MN, Duchaine TF, Jones RG. 2016. The miR-17~92 microRNA cluster is a global regulator of tumor metabolism. Cell Rep 16(7):1915–1928.

Rao VT, Khan D, Jones RG, Nakamura DS, Kennedy TE, Cui QL, Rone MB, Healy LM, Watson R, Ghosh S, Antel JP. 2016. Potential benefit of the charge-stabilized nanostructure saline RNS60 for myelin maintenance and repair. Sci Rep 6:30020.

Lampropoulou V, Sergushichev AA, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. 2016. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metab 24(1):158–166.

Sergushichev AA, Loboda AA, Jha AK, Vincent EE, Driggers EM, Jones RG, Pearce EJ, Artyomov MN. 2016. GAM: a web-service for integrated transcriptional and metabolic network analysis. Nucleic Acids Res 44(W1):W194–200.

Rone MB, Cui QL, Fang J, Wang LC, Zhang J, Khan D, Bedard M, Almazan G, Ludwin SK, Jones RG, Kennedy TE, Antel JP. 2016. Oligodendrogliopathy in multiple sclerosis: Low glycolytic metabolic rate promotes oligodendrocyte survival. J. Neurosci 36(17):4698–4707.

Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio PG, Krzyzaniak MA, King CG, Burgener A-V, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C. 2016. Memory CD8+ T cells require increased concentrations of acetate induced by stress for optimal function. Immunity 44(6):1312–1324.

Ma EH, Jones RG. 2016. (TORC)ing up purine biosynthesis. Science 351(6274):670–671.

Griss T, Vincent EE, Egnatchik R, Chen J, Ma EH, Faubert B, Viollet B, DeBerardinis RJ, Jones RG. 2015. Metformin suppresses cancer cell proliferation by suppressing mitochondrial-dependent biosynthesis. PLoS Biol 13(12):e1002309.

Ramiscal RR, Parish IA, Lee-Young RS, Babon JJ, Blagih J, Pratama A, Martin J, Hawley N, Cappello JY, Nieto PF, Ellyard JI, Kershaw NJ, Sweet RA, Goodnow CC, Jones RG, Febbraio MA, Vinuesa CG, Athanasopoulos V. 2015. Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation. eLife e08698.

Bott AJ, Peng I-C, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones RG, Wu S, Girnun G, Zong W-X. 2015. Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metab 22(6): 1068–1077.

Vincent EE, Sergushichev A, Griss T, Gingras M-C, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi T, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, Avizonis D, Pause A, Elder DJ, Artyomov MN, Jones RG. 2015. Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates metabolic adaptation and enables glucose-independent tumor growth. Mol Cell 60(2):195–207.

Dupuy F, Tabariès S, Andrzejewski S, Dong Z, Blagih J, Annis MG, Omeroglu A, Gao D, Leung S, Amir E, Clemons M, Aguilar-Mahecha A, Basik M, Vincent EE, St.-Pierre J, Jones RG, Siegel PM. 2015. PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer. Cell Metab 22(4):577–589.

Fu A, Robitaille K, Faubert B, Reeks C, Dai X-X, Hardy A, Sankar A, Rocheleau JV, Wheeler MB, MacDonald PE, Jones RG, Screaton RA. 2015. LKB1 couples glucose metabolism to insulin secretion. Diabetologia 58(7):1513–1522.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks O, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St.-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt S-M. 2015. A roadmap for interpreting 13C metabolite labeling patterns from cells. Current Opin Biotechnol 34:189–201.

Belle JI, Langlais D, Petrov JC, Pardo M, Jones RG, Gros P, Nijnik A. 2015. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1-deficiency. Blood 125(15):2344–2348.

Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vazquez G, Yurchenko E, Raissi TC, van der Windt GJW, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG. 2015. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity 42(1):41–54.

Vincent EE, Coelho PP, Blagih J, Griss T, Viollet B, Jones RG. 2015. Differential effects of AMPK agonists on cell growth and metabolism. Oncogene 34(28):3627–3639.

Poffenberger MC, Jones RG. 2014. Amino acids fuel T cell-mediated inflammation. Immunity 40(5):635– 637.

Yan M, Gingras MC, Dunlop EA, Nouët Y, Dupuy F, Jalali Z, Possik E, Coull BJ, Kharitidi D, Dydensborg AB, Faubert B, Kamps M, Sabourin S, Preston RS, Davies RS, Roughead T, Chotard L, van Steensel MA, Jones RG, Tee AR, Pause A. 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest 124(6):2640–2650.  

Possik E, Jalali Z, Nouët Y, Yan M, Gingras M-C, Schmeisser K, Panaite L, Kharitidi D, Dupuy F, Chotard L, Jones RG, Hall DH, Pause A. 2014. Folliculin regulates AMPK-dependent autophagy and metabolic stress survival. PLoS Genet 10(4):e1004273.

Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE. 2014. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med 211(4):653–668.

Everts B, Amiel E, Huang SC, Smith AM, Chang C-H, Lam WY, Redmann V, Frietas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ. 2014. TLR-driven early glycolytic reprogramming via TBK1-IKK the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323–332.

Faubert B, Vincent EE, Poffenberger MC, Jones RG. 2014. The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Lett. 356(2):165–170.  

Faubert B, Vincent EE, Griss T, Svensson R, Mamer OA, Avizonis D, Shaw RJ, Jones RG. 2014. Loss of LKB1 promotes metabolic reprogramming of cancer cells via HIF1. Proc Nat Acad Sci U S A 111(7):2554–2559.

McGuirk S, Gravel S-P, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St.-Pierre J. 2013. PGC-1alpha supports glutamine metabolism in breast cancer. Cancer Metab 1(1):22.

Pearce EL, Poffenberger M, Chang C-H, Jones RG. 2013. Fueling immunity: New insights on metabolism and lymphocyte function. Science 342(6155):1242454.

Dupuy F, Dong Z, Avizonis D, Ling C, Griss T, Siwak DR, Mills GB, Muller WJ, Siegel PM, Jones RG. 2013. LKB1 loss promotes ErbB2-driven breast cancer development but impairs the growth of lung metastases. Cancer Metab 1(1):18.

van der Windt GJW, O’Sullivan D, Everts B, Huang SC-C, Buck MD, Curtis JD, Chang C-H, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. 2013. Bioenergetic differences underlie the ‘rapid recall’ capability of CD8 memory T cells. Proc Nat Acad Sci U S A 110(35):14336–14341.

Chang C-H, Curtis JD, Maggi Jr LB, Faubert B, Villarino AV, O’Sullivan D, Huang SC-C, van der Windt GJW, Blagih J, Qui J, Weber JD, Pearce EJ, Jones RG, Pearce EL. 2013. Post-transcriptional control of T Cell effector function by aerobic glycolysis. Cell 153(6):1239–1251.

Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo A, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins P, Jones RG, Pollak MN, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD,  Sorensen PHB. 2013. The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell 153(5):1064–1079.

O’Shea JJ, Jones RG. 2013. Autoimmunity: Rubbing salt in the wound. Nature 496(7446):437–439.

Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, Tsuchihara K, Bungard D, Berger SL, Jones RG, Mak TW, Zaugg K. 2013. Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ 20(4):659–658.

Delisle J-S, Giroux M, Boucher G, Landry J-R, Hardy M-P, Lemieux S, Jones RG, Wilhelm BT, Perreault C. 2013. The TGF-/Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells. Genes Immun 14(2):115–126.

Faubert B, Boily B, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, DeBerardinis RJ, Siegel PM, Jones RG. 2013. AMPK is a negative regulator of the Warburg Effect and suppresses tumor growth in vivo. Cell Metab 17(1):113–124.

Christie DA, Mitsopoulos P, Blagih J, Dunn SD, St. Pierre J, Jones RG, Hatch GM, Madrenas J. 2012. SLP-2 deficiency in T cells is associated with impaired mitochondrial respiration and defective CD4+ T cell responses. J Immunol 189(9):4349–4360.

Blagih J, Krawczyk CM, Jones RG. 2012. LKB1 and AMPK: Central regulators of lymphocyte metabolism and function. Immunol Rev 249(1):59–71.

Blagih J, Jones RG. 2012. Polarizing macrophages through reprogramming of glucose metabolism. Cell Metab 15(6):793–795.

MacIver N, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG. 2011. The liver kinase B-1 (LKB1) is a central regulator of T cell development, activation, and metabolism. J Immunol 187(8):4187–4198.

Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, Huang P, Sawyer SK, Fuerth B, Faubert B, Kalliomaki T, Elia A, Luo X, Nadeem V, Bungard D, Yalavarthi S, Growney JD, Wakeham A, Moolani Y, Silvester J, Ten AY, Bakker W, Tsuchihara K, Berger SL, Hill RP, Jones RG, Tsao M, Robinson MO, Thompson CB, Pan JG, Mak TW. 2011. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev 25(10):1041–1051.

Bungard D, Fuerth B, Yang PY, Faubert B, Mass NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL. 2010. Signaling kinase AMPK regulates stress-promoted transcription via Histone H2B phosphorylation. Science 329(5996):1201–1205.

Moser TS, Jones RG, Thompson CB, Coyne CB, Cherry S. 2010. A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog. 6(6):e1000954.

Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. 2010. Toll-like receptor induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115(23):4742–4749.

Jones RG. 2009. The roles, mechanisms, and controversies of autophagy in mammalian biology. F1000 Biology Reports 1:68.  

Jones RG, Thompson CB. 2009. Tumor suppressors and cancer metabolism: a recipe for cancer growth. Genes Dev 23(5):537–548.  

Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y. 2009. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460(7251):103–107.

Jones RG, Thompson CB. 2007. Revving the engine: Signal transduction fuels T cell activation. Immunity 27(2):173–178.

Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang YL, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB. 2007. The proapoptotic factors Bax and Bak regulate T cell proliferation through control of endoplasmic reticulum Ca2+ homeostasis. Immunity 27(2):268–280.

Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. 2007. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67(14):6745–6752.

Saibil SD, Jones RG, Deenick EK, Liadis N, Elford AR, Vainberg MG, Baerg H, Woodgett JR, Gerondakis S, Ohashi PS. 2007. CD4+ and CD8+ T cell survival is regulated differentially by PKC, c-Rel and PKB. J Immunol 178(5):2932–2939.

Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. 2006. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21:521–531.

Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons MR, Krawczyk CM, Gerondakis S, Yeh W-C, Woodgett JR, Boothby MR, Ohashi PS. 2005. NF-kB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. J Immunol 175:3790–3799.

Buzzai M, Bauer DE, Jones RG, DeBerardinis RJ, Hatzivassiliou G, Elstrom RL, Thompson CB. 2005. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid b-oxidation. Oncogene 24(26):4165–4173.

Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18(3):283–293.

Krawczyk CM, Jones RG, Atfield A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM. 2005. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol 174(3):1472–1478.

Jeon MS, Atfield A, Venuprasad K, Krawczyk CM, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones RG, Gronski M, Ohashi P, Wada T, Bloom D, Fathman CG, Liu YC, Penninger JM. 2004. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21(2):167–177.

Berg-Brown NN, Gronski MA, Jones RG, Elford AR, Deenick EK, Odermatt B, Littman DR, Ohashi PS. 2004. PKC signals activation versus tolerance in vivo. J Exp Med 199(6):743–752.

Jones RG. 2003. CD28 signaling and T cell death. Mod Asp Immunobiol 3(1):4–5.

Jones RG, Elford AE, Parsons MJ, Wu L, Krawczyk CM, Yeh W-C, Hakem R, Rottapel R, Woodgett JR,  Ohashi PS. 2002. CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. J Exp Med 196(3):335–348.

Parsons MJ, Jones RG, Tsao M-S, Odermatt B, Woodgett JR, Ohashi PS. 2001. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. J Immunol 167(1):42–48.

Garza KM, Nguyen LT, Jones RG, Ohashi PS. 2001. Factors contributing to autoimmune disease. Adv Exp Med Biol 490:7–19.  

Krawczyk CM, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. 2000. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13(4):463–473.

Ohteki T, Parsons M, Zakarian A, Jones RG, Nguyen LT, Woodgett JR, Ohashi PS. 2000. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med 192(1):99–104.

Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, Ohashi PS. 2000. Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med 191(10):1721–1734.

Mariathasan S, Jones RG, Ohashi PS. 1999. Signals involved in thymocyte positive and negative selection. Semin Immunol 11(4):263–272.

Sebzda E, Mariathasan S, Ohteki T, Jones RG, Bachmann MF, Ohashi PS. 1999. Selection of the T cell repertoire. Annu Rev Immunol 17:829–874.  

Sasaki T, Irie-Sasaki J, Jones RG, Oliveira dos Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. 1999. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287(5455): 1040–1046.

Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM. 1998. X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2. Science 280(5367):1277–1281.